Mechanism-based predictions of interactions.

Mechanism-based predictions of interactions.

Exposure to more than one toxic compound is common in real life. The resulting toxic effects are often more than the simple sum of the effects of the individual compounds. It is unlikely that it will ever be possible to test all combinations. It is therefore highly desirable to improve or develop means for reasonably approximating predictions of interactions. In order to be valid and extrapolat...

Microbe interactions undermine predictions.

C R E D IT : C H R IS S C H M ID T /I S T O C K P H O T O .C O M Response ZAITSEV RAISES A VALID ARGUMENT FOR increasing student support services. It is good to see faculty understanding of the obstacles that community college students face. I certainly agree that more resources should be devoted to student guidance, tutoring services, and fi nancial aid, and I strongly advocate for the importa...

Historical contingency in species interactions: towards niche-based predictions

The way species affect one another in ecological communities often depends on the order of species arrival. The magnitude of such historical contingency, known as priority effects, varies across species and environments, but this variation has proven difficult to predict, presenting a major challenge in understanding species interactions and consequences for community structure and function. He...

computational predictions of intracellular thiazovivin interactions as one of the best hescs apoptosis inhibitors

Evolutionary predictions of binding surfaces and interactions.

Rapid progress in structural biology and whole-genome sequencing technology means that, for many protein families, structural and evolutionary information are readily available. Recent developments demonstrate how this information can be integrated to identify canonical determinants of protein structure and function. Among these determinants, those residues that are on protein surfaces are espe...